Abstract Background Betaine, an osmoprotective compatible solute, has been used to improve l-threonine production in engineered Escherichia coli l-threonine producer.Betaine supplementation upregulates the expression of zwf encoding glucose-6-phosphate dehydrogenase, leading to the increase of NADPH, which is beneficial for l-threonine production.I
Radiation therapy (RT) is an effective strategy for the treatment of localized prostate cancer (PCa) as well as local invasion.However, some locally advanced cancers develop radiation resistance and recur after therapy; therefore, the head total joy 2023 development of radiation-sensitizing compounds is essential for treatment of these tumors.DOC-2
Between 12 and 19 July 2021, a quasi-stationary atmospheric low-pressure system head total joy 2023 named Bernd caused intense precipitation on already-saturated soil, resulting in severe flooding in Germany, Belgium, and the Netherlands.The Ahr Valley in Rhineland-Palatinate was particularly affected, with approximately 42 000 residents impacted,